Congenital Chylothorax Complicated with Hemotho- rax after OK-432 Pleurodesis
نویسندگان
چکیده
Background: Congenital chylothorax is the most common cause of pleural effusion in newborn infants. These infants show signs of respiratory distress at birth. Chemical pleurodesis with OK-432 has recently been proposed for cases of persistent congenital chylothorax as an alternative method to surgery. Here we report a case of neonate with congenital chylothorax who developed hemothorax and shock as received OK-432 pleurodesis. Finally, his congenital chylothorax responded to high dose of octreotide. Although very rare, clinicians should be aware that OK-432 intrapleural instillations may be complicated with hemothorax.(J Pediatr Resp Dis 2014;10:5-7)
منابع مشابه
Intrapleural injection of OK-432 as the primary in-utero treatment for fetal chylothorax.
Chylothorax is a rare congenital condition associated with significant perinatal mortality and morbidity. Previous treatments with repeated thoracocentesis or thoracoamniotic shunting were technically demanding, and associated with significant procedure-related complications and neonatal complications. Here we report the first successful case in Hong Kong treated by a simple and effective inter...
متن کاملChylothorax after left side pneumothorax surgery managed by OK-432 pleurodesis: an effective alternative.
Chylothorax, a relatively rare complication of thoracic surgery, mostly occurs on the right side. We present a 16-year-old male who received thoracoscopic surgery for left spontaneous pneumothorax. Chylothorax developed on the postoperative 2(nd) day and resolved after diet control on the 4(th) day. Unfortunately, chylothorax recurred 2 weeks later. Chest drainage and nil per os with total pare...
متن کاملSuccessful pleurodesis with OK-432 in preterm infants with persistent pleural effusion
OK-432 (picibanil) is an inactivated preparation of Streptococcus pyogenes that causes pleurodesis by inducing a strong inflammatory response. Intrapleural instillation of OK-432 has recently been used to successfully treat neonatal and fetal chylothorax. Here we report a trial of intrapleural instillation of OK-432 in two preterm infants who were born with hydrops fetalis and massive bilateral...
متن کاملA Newborn with a Congenital Chylothorax
Congenital chylothorax is an uncommon cause of respiratory distress and a life-threatening condition in newborns. It is identified by abnormal accumulation of chyle in the pleural space. Herein, we report a male infant who was born by a successful vaginal delivery. After the first three days of life, he had feeding difficulties and cyanotic episodes during breastfeeding. On admission, physical ...
متن کاملGenome-Wide Gene Expression Analysis Implicates the Immune Response and Lymphangiogenesis in the Pathogenesis of Fetal Chylothorax
Fetal chylothorax (FC) is a rare condition characterized by lymphocyte-rich pleural effusion. Although its pathogenesis remains elusive, it may involve inflammation, since there are increased concentrations of proinflammatory mediators in pleural fluids. Only a few hereditary lymphedema-associated gene loci, e.g. VEGFR3, ITGA9 and PTPN11, were detected in human fetuses with this condition; thes...
متن کامل